Tagrix contains osimertinib, and adverse effects can range from manageable reactions to potentially serious complications.
Commonly reported effects
Depending on treatment setting, reported adverse effects can include:
- Diarrhea
- Rash
- Dry skin
- Nail-related changes
- Stomatitis
- Reduced appetite
- Fatigue
- Pruritus
- Cough
- Musculoskeletal symptoms
Combination therapy with chemotherapy can add adverse effects associated with the chemotherapy medicines.
Serious adverse reactions
Important risks include:
- Interstitial lung disease/pneumonitis
- QTc interval prolongation
- Cardiomyopathy
- Keratitis and other ocular toxicity
- Severe skin reactions
- Aplastic anemia
- Embryo-fetal toxicity
Beacon’s product information provides specific dose-modification instructions for several of these events.
Seek prompt medical assessment for
- New or worsening shortness of breath
- Significant cough or respiratory deterioration
- Fainting or severe palpitations
- New significant cardiac symptoms
- Severe eye pain or visual changes
- Extensive blistering or peeling of the skin
- Severe or unusual symptoms